Age of onset determines intrinsic functional brain architecture in Friedreich ataxia

Naeije, G., Wens, V., Coquelet, N., Sjøgård, M., Goldman, S., Pandolfo, M. and De Tiège, X.P. (2019). Ann Clin Transl Neurol. doi:10.1002/acn3.50966

Age of symptoms onset is a major determinant of FRDA patients' intrinsic functional brain architecture. Higher rsFC in FRDA patients with later age of symptoms onset supports compensatory mechanisms for FRDA‐related neural network dysfunction and position neuromagnetic rsFC as potential marker of FRDA neural reserve.