Our findings support the potential of in vivo sodium MRI to detect metabolic changes of increased total sodium concentration in the cerebellum and brainstem, the key regions in Friedreich ataxia. In addition to structural changes, sodium changes were present in cerebellar hemispheres and vermis without concomitant significant atrophy.
Wednesday, April 27, 2022
Increased brain tissue sodium concentration in Friedreich ataxia: a multimodal MR Imaging study
Janna Krahe, Imis Dogan, Claire Didszun, Shahram Mirzazade, Alexa Haeger, Nadim Joni Shah, Ilaria A. Giordano, Thomas Klockgether, Guillaume Madelin, Jörg B. Schulz, Sandro Romanzetti, Kathrin Reetz; NeuroImage: Clinical, 2022, 103025, ISSN 2213-1582, doi:10.1016/j.nicl.2022.103025.
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