Astrocyte Resilience to Oxidative Stress Induced by Insulin-like Growth Factor I (IGF-I) Involves Preserved AKT (Protein Kinase B) Activity

David Dávila, Silvia Fernández and Ignacio Torres-Alemán; The Journal of Biological Chemistry, 291, 2510-2523. doi: 10.1074/jbc.M115.695478

These results point out the importance of AKT activation for astrocyte survival during oxidative stress and reinforce the idea that modulation of astrocytes by IGF-I forms part of the brain responses to oxidative damage.