Longitudinal changes of SARA scale in Friedreich ataxia: Strong influence of baseline score and age at onset

Porcu, L., Fichera, M., Nanetti, L., Rulli, E., Giunti, P., Parkinson, M.H., Durr, A., Ewenczyk, C., Boesch, S., Nachbauer, W., Indelicato, E., Klopstock, T., Stendel, C., Rodríguez de Rivera, F.J., Schöls, L., Fleszar, Z., Giordano, I., Didszun, C., Castaldo, A., Rai, M., Klockgether, T., Pandolfo, M., Schulz, J.B., Reetz, K., Mariotti, C. and (2023), Longitudinal changes of SARA scale in Friedreich ataxia: Strong influence of baseline score and age at onset. Ann Clin Transl Neurol. doi:10.1002/acn3.51886 

 Analyses of statistical properties of SARA suggest a variable sensitivity of the scale at different disease stages, and provide important information for population selection and result interpretation in future clinical trials.