Obstructive Form of Hypertrophic Cardiomyopathy-Left Ventricular Outflow Tract Gradient: Novel Methods of Provocation, Monitoring of Biomarkers, and Recent Advances in the Treatment.

Pawel Petkow Dimitrow and Renata Rajtar-Salwa. Biomed Res Int. 2016; 2016: 1575130. Published online 2016 May 10. doi: 10.1155/2016/1575130

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From a practical point of view, the effective monitoring, including biochemical biomarkers indicating reduction of LVOT gradient, is important because this parameter has become a risk factor for sudden death in the 2014 ESC guideline. In this context, the maximized physiological LVOT gradient provocation stimulus seems to be an important diagnostic element. Novel invasive therapeutic techniques have been recently dynamically developed, providing attractive treatment opportunities.
Septal myectomy may be a viable option to relieve symptoms and interrupt progression of heart disease also in selected Friedreich's ataxia patients.