Tuesday, January 18, 2011

Systems biological approach on neurological disorders: a novel molecular connectivity to aging and psychiatric diseases

BMC Systems Biology 2011, 5:6doi:10.1186/1752-0509-5-6

Shiek S.S.J Ahmed, Abdul R. Ahameethunisa, Winkins Santosh, Srinivasa Chakravarthy and Suresh Kumar

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This study improves the understanding of the complex interactions that occur between neurological and psychiatric diseases with aging, which lead to determine the diagnostic markers. Also, the disease-disease association results could be helpful to determine the symptom relationships between neurological and psychiatric diseases. Together, our study presents many research opportunities in post-genomic biomarker development.

"this approach provides the additional information that PDHB is not only associated with Parkinson’s disease but also associated with Athetosis and Friedreich Ataxia"

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Information from cochlear potentials and genetic mutations helps localize the lesion site in auditory neuropathy

Genome Med 2010, 2:91 doi:10.1186/gm212

Rosamaria Santarelli, Department of Medical and Surgical Specialities, Service of Audiology and Phoniatrics, University of Padua

Keywords: Auditory neuropathy (AN), disruption of auditory nerve activity,  impairment of speech perception,  hearing loss, abnormality of auditory brainstem potentials, preserved outer hair-cell activities, multisystem involvement,  peripheral and optic neuropathies, abnormal cochlear potentials have been recorded from patients, genetically based auditory neuropathies,  molecular mechanisms.