Source: Nancy Ross-Flanigan. University of Michigan
Small Molecules Mimic Natural Gene Regulators
In the quest for new approaches to treating and preventing disease, one appealing route involves turning genes ........../...
These molecules can help scientists probe the transcription process and perhaps eventually be used to correct diseases that result from errors in gene regulation.
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Keywords: turning genes, cancer, diabetes, gene expression, transcriptional activators , CBP.
Original work:( http://pubs.acs.org/doi/abs/10.1021/cb900028j?prevSearch=David+Wemmer&searchHistoryKey= )
Amphipathic Small Molecules Mimic the Binding Mode and Function of Endogenous Transcription Factors
Sara J. Buhrlage†, Caleb A. Bates‡, Steven P. Rowe†, Aaron R. Minter†, Brian B. Brennan†, Chinmay Y. Majmudar†, David E. Wemmer§, Hashim Al-Hashimi†
and Anna K. Mapp†‡¶*
and Anna K. Mapp†‡¶* † Department of Chemistry ‡ Department of Medicinal Chemistry Department of Biophysics ¶ Program in Chemical Biology, University of Michigan, Ann Arbor, Michigan, 48109 § Department of Chemistry, University of California, Berkeley, California 94720
Department of Biophysics ¶ Program in Chemical Biology, University of Michigan, Ann Arbor, Michigan, 48109 § Department of Chemistry, University of California, Berkeley, California 94720ACS Chem. Biol., 2009, 4 (5), pp 335–344
DOI: 10.1021/cb900028j
Publication Date (Web): April 6, 2009
Copyright © 2009 American Chemical Society
