Ignacio Hugo Castro, María Florencia Pignataro, Karl Ellioth Sewell, Lucía Daniela Espeche, María Georgina Herrera, Martín Ezequiel Noguera, Liliana Dain, Alejandro Daniel Nadra, Martín Aran, Clara Smal, Mariana Gallo, Javier Santos(2019). Frataxin Structure and Function. In: Harris J., Marles-Wright J. (eds) Macromolecular Protein Complexes II: Structure and Function. Subcellular Biochemistry, vol 93. Springer, Cham. DOI:10.1007/978-3-030-28151-9_13
By combining multiple experimental tools including high resolution techniques like NMR and X-ray, but also SAXS, crosslinking and mass-spectrometry, it was possible to build a reliable model of the structure of the desulfurase supercomplex NFS1/ACP-ISD11/ISCU/frataxin. In this chapter, we explore these issues showing how the scientific view concerning frataxin structure-function relationships has evolved over the last years.
Thursday, January 23, 2020
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