RNA-INDUCED TRANSCRIPTIONAL GENE SILENCING IN FRIEDREICH ATAXIA

RNA-INDUCED TRANSCRIPTIONAL GENE SILENCING IN FRIEDREICH ATAXIA. PROJECT: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

Project Number: 5R01NS072418-04
Project Leader: BIDICHANDANI, SANJAY I
Awardee Organization: UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR

Turn up the power - pharmacological activation of mitochondrial biogenesis in mouse models

Turn up the power - pharmacological activation of mitochondrial biogenesis in mouse models. J C Komen and D R Thorburn; British Journal of Pharmacology, Accepted manuscript online: 17 SEP 2013 11:12PM EST | DOI: 10.1111/bph.12413

Keywords: mitochondria; oxidative phosphorylation; PGC-1α; mitochondrial biogenesis; bezafibrate; resveratrol; AICAR; mouse models; mitochondrial disease

Exercise Induces Hippocampal BDNF through a PGC-1α/FNDC5 Pathway

Exercise Induces Hippocampal BDNF through a PGC-1α/FNDC5 Pathway. Christiane D. Wrann, James P. White, John Salogiannnis, Dina Laznik-Bogoslavski, Jun Wu, Di Ma, Jiandie D. Lin, Michael E. Greenberg, Bruce M. Spiegelman; Cell Metabolism, Available online 10 October 2013. http://dx.doi.org/10.1016/j.cmet.2013.09.008

This findings link endurance exercise and the important metabolic mediators, PGC-1α and FNDC5, with BDNF expression in the brain.