Exercise Induces Hippocampal BDNF through a PGC-1α/FNDC5 Pathway

Exercise Induces Hippocampal BDNF through a PGC-1α/FNDC5 Pathway. Christiane D. Wrann, James P. White, John Salogiannnis, Dina Laznik-Bogoslavski, Jun Wu, Di Ma, Jiandie D. Lin, Michael E. Greenberg, Bruce M. Spiegelman; Cell Metabolism, Available online 10 October 2013. http://dx.doi.org/10.1016/j.cmet.2013.09.008

This findings link endurance exercise and the important metabolic mediators, PGC-1α and FNDC5, with BDNF expression in the brain.