Sirt1 acts in association with PPARα to protect the heart from hypertrophy, metabolic dysregulation, and inflammation

Cardiovasc Res (2011) 90 (2): 276-284. doi: 10.1093/cvr/cvq376

Ana Planavila1,2,*, Roser Iglesias1,2, Marta Giralt1,2 and Francesc Villarroya1,2

1Departament de Bioquímica i Biologia Molecular, Institut de Biomedicina de la Universitat de Barcelona (IBUB), Universitat de Barcelona, Avda Diagonal 645, Barcelona E-08028, Spain
2CIBER Fisiopatología de la Obesidad y Nutrición (CIBEROBN), Barcelona, Spain

"Collectively, these findings reveal a major involvement of the Sirt1–PPARα interaction in the protective role of Sirt1 against cardiac hypertrophy."

Friedreich's ataxia: Past, present and future

doi:10.1016/j.brainresrev.2011.04.001

Daniele Marmolino,
Laboratoire de Neurologie experimentale, Universite Libre de Bruxeles (ULB), Route de Lennik 808, Campus Erasme - 1070 Bruxelles, Belgium

Keywords: Friedreich's ataxia; Frataxin; GAA; Iron; Fe-S clusters; Oxidative stress; FRDA pathogenesis; frataxin function; new treatments; animal and cellular models.