Theresa A. Zesiewicz, Jeannie B. Stephenson, Seok Hun Kim, Kelly L. Sullivan, Israt Jahan, Yangxin Huang, Jason L. Salemi, Lynn Wecker, Jessica D. Shaw, Clifton L. Gooch, Gait & Posture, Available online 30 March 2017, ISSN 0966-6362, doi:10.1016/j.gaitpost.2017.03.019.
In the FA group, comfortable and fast gait velocity declined 8.0% and 13.9% after 12 months and 24.1% and 30.3% after 24 months, respectively. Postural stability indices increased in FA subjects an average of 41% from baseline to 24 months, representing a decline in balance. Subjects with FA also demonstrated a 17.7% increase in FARS neurological exam scores over 24 months. There were no changes in gait or balance variables in controls. In the FA group, multiple gait and balance measures correlated significantly with FARS neurological exam scores.
The GAITRite and Biodex systems provided objective and clinically relevant measures of functional decline in subjects with FA that correlated significantly with performance measures in the FARS. Gait velocity may be an important objective measure to identify disease progression in adults with FA.
Friday, March 31, 2017
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