Yeast as a Tool for Deeper Understanding of Human Manganese-Related Diseases

Louise Thines, Antoine Deschamps, Jiri Stribny and Pierre Morsomme; Genes 2019, 10(7), 545; (Review) doi:10.3390/genes10070545

Several manganese-related pathologies whose molecular mechanisms have been studied in yeast are then presented in the light of the function of this cation as a non-enzymatic antioxidant or as a key cofactor of metalloenzymes. In this line, we first describe the Transmembrane protein 165-Congenital Disorder of Glycosylation (TMEM165-CDG) and Friedreich ataxia pathologies.