Iron-Starvation-Induced Mitophagy Mediates Lifespan Extension upon Mitochondrial Stress in C. elegans. Alfonso Schiavi, Silvia Maglioni, Konstantinos Palikaras, Anjumara Shaik, Flavie Strapazzon, Vanessa Brinkmann, Alessandro Torgovnick, Natascha Castelein, Sasha De Henau, Bart P. Braeckman, Francesco Cecconi, Nektarios Tavernarakis, Natascia Ventura; Current Biology, Available online 2 July 2015, ISSN 0960-9822, http://dx.doi.org/10.1016/j.cub.2015.05.059.
Mitochondrial autophagy is an evolutionarily conserved response to frataxin silencing, mitophagy is activated in response to mitochondrial stress. Mitophagy induction is part of an adaptive iron starvation response induced as a protective mechanism against mitochondrial stress, thus suggesting novel potential therapeutic strategies for the treatment of mitochondrial disorders.
Friday, July 3, 2015
Targeting lipid peroxidation and mitochondrial imbalance in Friedreich's ataxia
Targeting lipid peroxidation and mitochondrial imbalance in Friedreich's ataxia. Rosella Abeti, Ebru Uzun, Indhushri Renganathan, Tadashi Honda, Mark A. Pook, Paola Giunti, Pharmacological Research, Available online 2 July 2015, ISSN 1043-6618, http://dx.doi.org/10.1016/j.phrs.2015.05.015.
Two different categories of protective compounds: deuterised poly-unsaturated fatty acids (dPUFAs) and Nrf2-inducers have been shown to protect the cell from damage induced by lipid peroxidation and the latter trigger Nrf2 antioxidant pathway.
Two different categories of protective compounds: deuterised poly-unsaturated fatty acids (dPUFAs) and Nrf2-inducers have been shown to protect the cell from damage induced by lipid peroxidation and the latter trigger Nrf2 antioxidant pathway.
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