Complement-Derived Anaphylatoxin C3a Regulates In Vitro Differentiation and Migration of Neural Progenitor Cells

STEM CELLS
Volume 27 Issue 11;Pages 2824-2832
Published Online: 25;Sep;2009
Noriko Shinjyo ¹, Anders Ståhlberg ², Mike Dragunow ³, Milos Pekny ², Marcela Pekna ^{1 *¶1}Department of Medical Chemistry and Cell Biology, Institute of Biomedicine, Rehabilitation, Institute of Neuroscience and Physiology, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden
²Center for Brain Repair and Rehabilitation, Department of Clinical Neuroscience and Rehabilitation, Institute of Neuroscience and Physiology, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden
³Department of Pharmacology and The National Research Centre for Growth and Development, Faculty of Medical and Health Sciences, The University of Auckland, Auckland, New Zealand

Keywords: C3a, ERK1/2 phosphorylation, Neural progenitor cells, Neuronal differentiation, Migration, neuroprotection, neurogenesis.

New Discovery About Formation of New Brain Cells

ScienceDaily (Nov. 23, 2009) — The generation of new nerve cells in the brain is regulated by a peptide known as C3a, which directly affects the stem cells' maturation into nerve cells and is also important for the migration of new nerve cells through the brain tissue, reveals new research from the Sahlgrenska Academy published in the journal Stem Cells. (read more)

A Periplasmic Reducing System Protects Single Cysteine Residues from Oxidation

(Related to the previous post, the source paper of the previus news)

Science 20 November 2009, Vol. 326. no. 5956, pp. 1109 - 1111, DOI: 10.1126/science.1179557
Matthieu Depuydt,1 Stephen E. Leonard,2 Didier Vertommen,1 Katleen Denoncin,1 Pierre Morsomme,3 Khadija Wahni,4,5 Joris Messens,4,5 Kate S. Carroll,2 Jean-François Collet1,*

de Duve Institute, Université catholique de Louvain, B-1200 Brussels, Belgium.
2 Life Sciences Institute, University of Michigan, Ann Arbor, MI 48109–1048, USA.
3 Institut des Sciences de la Vie, Université catholique de Louvain, B-1348 Louvain-la-Neuve, Belgium.
4 Department of Molecular and Cellular Interactions, Vlaams Instituut voor Biotechnologie (VIB), Vrije Universiteit Brussel, B-1050 Brussels, Belgium.
5 Structural Biology Brussels, Vrije Universiteit Brussel, B-1050 Brussels, Belgium.

Keywords:  thiol group, cysteine,  disulfide bonds, oxidation,  sulfenic acids, sulfonic acids,  DsbG, DsbC,  thioredoxin-related proteins.

Saving The Single Cysteine: New Antioxidant System Found

Medical News Today, Article Date: 23 Nov 2009 - 1:00 PST
We've all read studies about the health benefits of having a life partner. The same thing is true at the molecular level, where amino acids known as cysteines are much more vulnerable to damage when single than when paired up with other cysteines.  read more....

Keywords: cysteines, new antioxidant system, DsbG, hyperoxidation, antioxidant therapies,

GUÍA PRÁCTICA DE NECESIDADES EDUCATIVAS ESPECIALES

Original book : At a glance: a practical guide to children's special needs

Autor: Viv EAST y Linda EVANS
Traductor: Pablo Manzano
ISBN: 978-84-7112-609-2
Fecha de la edición: 25/11/2009

Keywors: Necesidades Educativas Especiales, Ataxia de Friedreich, Plan Educativo Individualizado (PEI)

Búsqueda y análisis de fármacos en modelos de ataxia de Friedreich

Ros Cantera, Sheila,
Tesis doctoral del Departamento de Genética de la UV.
Editorial: Instituto de Biomedicina de Valencia, CSIC; Universitat de València, Fecha de publicación: 17-Sep-2009

Keywords: Ataxia de Friedreich, Frataxina, Riboflavina, deferiprona, deferoxamina, amrinona, crisina,


Trabajo completo / full text : http://digital.csic.es/bitstream/10261/17120/1/Tesis%20Sheila%20Ros.pdf