Monday, August 29, 2016

Neurobehavioral deficits in the KIKO mouse model of Friedreich's ataxia

Marissa Z. McMackin, Chelsea K. Henderson, Gino A. Cortopassi, Behavioural Brain Research SreeTestContent1 SreeTestContent1, Available online 26 August 2016, ISSN 0166-4328, doi:/10.1016/j.bbr.2016.08.053.

The KIKO mouse is an animal model of FA with frataxin deficiency first described in 2002, but neurobehavioral deficits have never been described in this model. The identification of robust neurobehavioral deficits in KIKO mice could support the testing of drugs for FA.