Iron-frataxin involved in the protective effect of quercetin against alcohol-induced liver mitochondrial dysfunction

Liu J, Chen H, Lin H, Peng S, Chen L, Cheng X, Yao P, Tang Y.; J Nutr Biochem. 2022 Dec 29:109258. doi: 10.1016/j.jnutbio.2022.109258. Epub ahead of print. PMID: 36587874. 

 Frataxin deficiency reduced the protective effects of quercetin on mitochondria disordered by ethanol.

Drosophila melanogaster frataxin: protein crystal and predicted solution structure with identification of the iron-binding regions

Rodrigues AV, Batelu S, Hinton TV, Rotondo J, Thompson L, Brunzelle JS, Stemmler TL.; Acta Crystallogr D Struct Biol. 2023 Jan 1;79(Pt 1):22-30. doi: 10.1107/S2059798322011639. Epub 2023 Jan 1. PMID: 36601804. 

 The goal of this report is to provide structural details of the Drosophila melanogaster frataxin ortholog (Dfh), using both X-ray crystallography and nuclear magnetic resonance (NMR) spectroscopy, in order to provide the foundational insight needed to understand the structure-function correlation of the protein.

Histopathology of the cerebellar cortex in essential tremor and other neurodegenerative motor disorders: comparative analysis of 320 brains

Elan D. Louis, Regina T. Martuscello, John T. Gionco, Whitney G. Hartstone, Jessica B. Musacchio, Marisa Portenti, Morgan McCreary, Sheng-Han Kuo, Jean-Paul G. Vonsattel & Phyllis L. Faust; Acta Neuropathol (2023). doi:10.1007/s00401-022-02535-z 

We conducted comparative analyses in a postmortem series of 320 brains on the severity and patterning of cerebellar cortex degenerative changes in ET (n = 100), other neurodegenerative disorders of the cerebellum [spinocerebellar ataxias (SCAs, n = 47, including 13 SCA3 and 34 SCA1, 2, 6, 7, 8, 14); Friedreich’s ataxia (FA, n = 13); multiple system atrophy (MSA), n = 29], and other disorders that may involve the cerebellum [Parkinson’s disease (PD), n = 62; dystonia, n = 19] versus controls (n = 50).