Neuroprotection using gene therapy to induce vascular endothelial growth factor-A expression

Gene Therapy (2009) 16, 1292–1299; doi:10.1038/gt.2009.111;
S A Sakowski1, S B Heavener2,5, J S Lunn1, K Fung3, S S Oh1, S K Spratt4, N D Hogikyan2 and E L Feldman1

1Department of Neurology, University of Michigan Medical Center, Ann Arbor, MI, USA
2Department of Otolaryngology-Head and Neck Surgery, University of Michigan Medical Center, Ann Arbor, MI, USA
3Department of Otolaryngology, University of Western Ontario, London, Ontario, Canada
4Sangamo BioSciences, Inc., Richmond, CA, USA

Keywords:zinc-finger protein (ZFP) transcription factors, adenoviral vectors, Ad-32Ep65-Flag (Ad-p65), VEGF, increase in axon outgrowth, neuroprotective effects, laryngeal nerve (RLN)-crush injury, nerve regeneration, nerve injury, neurodegeneration.