Olivier Reelfs, Vincenzo Abbate, Agostino Cilibrizzi, Mark A. Pook, Robert C. Hider and Charareh Pourzan;DOI:10.1039/C8MT00257F
Our results reveal a link between FRDA as a disease of mitochondrial iron overload and sensitivity to UVA of skin fibroblasts. Our findings suggest that the high levels of mitochondrial LI in FRDA cells which contribute to high levels of mitochondrial ROS production after UVA irradiation are likely to play a crucial role in the marked sensitivity of these cells to UVA-induced oxidative damage. This study may have implications not only for FRDA but also for other diseases of mitochondrial iron overload, with the view to develop topical mitochondria-targeted iron chelators as skin photoprotective agents.
Wednesday, February 20, 2019
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