Current Experience in Testing Mitochondrial Nutrients in Disorders Featuring Oxidative Stress and Mitochondrial Dysfunction: Rational Design of Chemoprevention Trials

Current Experience in Testing Mitochondrial Nutrients in Disorders Featuring Oxidative Stress and Mitochondrial Dysfunction: Rational Design of Chemoprevention Trials. Giovanni Pagano, Annarita Aiello Talamanca, Giuseppe Castello, Mario D. Cordero, Marco d'Ischia, Maria Nicola Gadaleta, Federico V. Pallardó, Sandra Petrović, Luca Tiano and Adriana Zatterale; Int. J. Mol. Sci. 2014, 15(11), 20169-20208; doi:10.3390/ijms151120169

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Mammalian frataxin directly enhances sulfur transfer of NFS1 persulfide to both ISCU and free thiols.

Mammalian frataxin directly enhances sulfur transfer of NFS1 persulfide to both ISCU and free thiols. Aubérie Parent, Xavier Elduque, David Cornu, Laura Belot, Jean-Pierre Le Caer, Anna Grandas, Michel B. Toledano, Benoit D’Autréaux; Nature Communications 6, doi:10.1038/ncomms6686, Published 19 January 2015

These data raise important questions on the physiological mechanism of Fe-S cluster assembly and point to a unique function of ​frataxin as an enhancer of sulfur transfer within the ​NFS1–​ISD11–​ISCU complex.

The cerebellum and sleep

The cerebellum and sleep. DelRosso LM, Hoque R; Neurologic clinics 32:4 2014 Nov pg 893-900 doi:10.1016/j.ncl.2014.07.003

The cerebellum has an important role in sleep. Certain sleep disorders have demonstrated decreased activity in the cerebellum, and sleep complaints are common in patients with cerebellar diseases such as spinocerebellar ataxia, Friedreich ataxia, Joubert syndrome, and ataxia-telangiectasia.