Evidence that yeast frataxin is not an iron storage protein In Vivo

Biochimica et Biophysica Acta (BBA) - Molecular Basis of DiseaseArticle in Press, Accepted Manuscript, doi:10.1016/j.bbadis.2010.03.008

Alexandra Seguin^{a, 1}, Robert Sutak^{a, 1}, Anne-Laure-Bulteau^b, Richard Garcia-Serres^c, Jean-Louis Oddou^c, Sophie Lefevre^a, Renata Santos^a, Andrew Dancis^d, Jean-Michel Camadro^a, Jean-Marc Latour^{c, 2} and Emmanuel Lesuisse^{a, 2, ,}

^a Laboratoire Mitochondries, Métaux et Stress oxydant, Institut Jacques Monod, CNRS-Université Paris Diderot, France.
^b Laboratoire de Biologie et Biochimie Cellulaire du Vieillissement, Université Paris 7, Paris, France.
^c CEA, iRTSV, LCBM, 38054 Grenoble Cedex 9, France; CNRS, UMR5249, Grenoble, France; Université Joseph Fourier, 38054 Grenoble Cedex 9, France
^d University of Pennsylvania, Department of Medicine, Division of Hematology/Oncology, BRBII Room 731, 431 Curie Blvd, Philadelphia PA 19104, USA

Received 10 October 2009; 

revised 14 March 2010; 

accepted 16 March 2010. 

Available online 20 March 2010.

Keyword:  Yeast frataxin; iron; oxidative stress; yfh1; ggc1; Mössbauer; mitochondria