Adaptation of the heart to Frataxin depletion: Evidence that integrated stress response can predominate over mTORC1 activation

César Vásquez-Trincado, Monika Patel, Aishwarya Sivaramakrishnan, Carmen Bekeová, Lauren Anderson-Pullinger, Nadan Wang, Hsin-Yao Tang, Erin L Seifert, Human Molecular Genetics, 2021;, ddab216, doi:10.1093/hmg/ddab216

Altogether, these findings suggest that the FXN depleted heart can suppress a major ATP demanding process such as protein translation, which, together with some preservation of β-oxidation, could be adaptive, at least in the short term.