Mammalian iron–sulphur proteins: novel insights into biogenesis and function

Mammalian iron–sulphur proteins: novel insights into biogenesis and function. Tracey A. Rouault; Nature Reviews Molecular Cell Biology (2014), doi:10.1038/nrm3909 published online 26 November 2014

Fe–S clusters are probably an unrecognized and elusive cofactor of many known proteins.

Transcription-Coupled Nucleotide Excision Repair Factors Promote R-Loop-Induced Genome Instability

Transcription-Coupled Nucleotide Excision Repair Factors Promote R-Loop-Induced Genome Instability. Pages Julie Sollier, Caroline Townsend Stork, María L. García-Rubio, Renee D. Paulsen, Andrés Aguilera, Karlene A. Cimprich; Molecular Cell, Available online 26 November 2014, DOI: http://dx.doi.org/10.1016/j.molcel.2014.10.020

An enzyme that fixes broken DNA sometimes destroys it instead

An enzyme that fixes broken DNA sometimes destroys it instead. Medicalxpress. November 26, 2014

"Recent work has also implicated these hybrids in neurodegenerative diseases, including Fragile X syndrome, Friedreich's ataxia and amyotrophic lateral sclerosis type 4," said Julie Sollier, PhD, the lead author of the paper and a postdoctoral researcher. "We would like to explore the potential role of the endonucleases we identified in these diseases as well."

Pain and itch in a dish: Scientists convert human skin cells into sensory neurons

Pain and itch in a dish: Scientists convert human skin cells into sensory neurons. ScienceDaily. www.sciencedaily.com/releases/2014/11/141125104338.htm (accessed November 26, 2014).

Source: The Scripps Research Institute

These neurons are also affected by spinal cord injury and involved in Friedreich's ataxia.


Journal Reference: Selective conversion of fibroblasts into peripheral sensory neurons. Joel W Blanchard, Kevin T Eade, Attila Szűcs, Valentina Lo Sardo, Rachel K Tsunemoto, Daniel Williams, Pietro Paolo Sanna, Kristin K Baldwin. Nature Neuroscience, 2014; DOI: 10.1038/nn.3887