Mitochondrial Dysfunction Leads to Nuclear Genome Instability via an Iron-Sulfur Cluster Defect

Comment: Although in the FA we have not problems with the mtDNA, the genetic information of frataxin is in nDNA, this is a very interesting article.

Cell, Volume 137, Issue 7, 26 June 2009, Pages 1247-1258

http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6WSN-4WM10D8-J&_user=10&_rdoc=1&_fmt=&_orig=search&_sort=d&_docanchor=&view=c&_searchStrId=978708264&_rerunOrigin=scholar.google&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=c8d80ad217bf0eefe71a1bba6364c95a


Joshua R. Veatch1, 2, Michael A. McMurray1, 2, 3, Zara W. Nelson1 and Daniel E. Gottschling1, ,
1Division of Basic Sciences, Fred Hutchinson Cancer Research Center, University of Washington, Seattle, WA 98109, USA
2The Molecular and Cellular Biology Program, University of Washington, Seattle, WA 98109, USA
3Present address: Department of Molecular and Cell Biology, University of California at Berkeley, Berkeley, CA 94720, USA

Keywords: mitochondrial genome (mtDNA), inestability of the nuclear genome, defect in iron-sulfur cluster (ISC) biogenesis, ISC protein biogenesis.