We describe the case of a 21‐year‐old patient affected by Friedreich's ataxia on wheel‐chair, with initial cardiac involvement and electrocardiographic features characterized by thiamine treatment‐related negative T wave and QTc variations. We discuss plausible physiopathology and potential ECG role implications as an intermediate marker of treatment response in future clinical trials considering patients affected by Friedreich's ataxia.
Friday, November 6, 2020
Electrocardiogram in Friedreich's ataxia: A short‐term surrogate endpoint for treatment efficacy
Sandra Mastroianno MD Michele Germano MD Angela Maggio MD Raimondo Massaro MD Domenico Rosario Potenza MD Aldo Russo MD Massimo Carella PhD Giuseppe Di Stolfo MD, PhD; Ann Noninvasive Electrocardiol. 2020; 00:e12813. doi:10.1111/anec.12813
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