Tuesday, October 9, 2018

Corneal Confocal Microscopy: Neurologic Disease Biomarker in Friedreich's Ataxia

Odelya E. Pagovich MD Mary L. Vo MD Zijun Zhao BA Ioannis N. Petropoulos PhD Michelle Yuan BA Buntitar Lertsuwanroj MD Jessica Ciralsky MD Edward Lai MD Szilard Kiss MD Donald J. D'Amico MD Jason G. Mezey PhD Rayaz A. Malik PhD Ronald G. Crystal MD; Ann Neurol. Accepted Author Manuscript. First published: 07 October 2018, doi:10.1002/ana.25355

CCM demonstrated a significant reduction in nerve fiber density and length in FRDA compared to healthy controls. Importantly, CCM parameters correlated with genotype, SARA and FARS neurological scales, and linear regression modeling of CCM nerve parameters generated equations that predict the neurologic severity of FRDA.