Targeting lipid peroxidation and mitochondrial imbalance in Friedreich's ataxia

Targeting lipid peroxidation and mitochondrial imbalance in Friedreich's ataxia. Rosella Abeti, Ebru Uzun, Indhushri Renganathan, Tadashi Honda, Mark A. Pook, Paola Giunti, Pharmacological Research, Available online 2 July 2015, ISSN 1043-6618, http://dx.doi.org/10.1016/j.phrs.2015.05.015.

Two different categories of protective compounds: deuterised poly-unsaturated fatty acids (dPUFAs) and Nrf2-inducers have been shown to protect the cell from damage induced by lipid peroxidation and the latter trigger Nrf2 antioxidant pathway.