Frataxin is always present in all eukaryotes, it seems essential to life, surprisingly in this paper describes an organism that lacks frataxin, perhaps a more detailed study of this protist would give clues to understand the frataxin function, and help to understand their relationship with the Fe-S clusters.
PLoS ONE 6(2): e17285. doi:10.1371/journal.pone.0017285
Petr L. Jedelský1,2, Pavel Doležal1, Petr Rada1, Jan Pyrih1, Ondřej Šmíd1, Ivan Hrdý1, Miroslava Šedinová1, Michaela Marcinčiková1, Lubomír Voleman1, Andrew J. Perry3, Neritza Campo Beltrán1, Trevor Lithgow3, Jan Tachezy1*
1 Department of Parasitology, Faculty of Science, Charles University in Prague, Prague, Czech Republic, 2 Laboratory of Mass Spectrometry, Faculty of Science, Charles University in Prague, Prague, Czech Republic, 3 Department of Biochemistry & Molecular Biology, Monash University, Clayton Campus, Melbourne, Australia
A striking deviation from other eukaryotes is the absence of frataxin in Giardia mitosomes. Frataxin is invariably present in eukaryotes that contain the ISC-type FeS cluster assembly machinery.
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Friday, February 25, 2011
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