Role of Frataxin, a Protein Implicated in Friedreich Ataxia, in Making Iron-Sulfur Clusters

Role of Frataxin, a Protein Implicated in Friedreich Ataxia, in Making Iron-Sulfur Clusters. The Journal of Biological Chemistry, 288, 36787. December 27, 2013; 10.1074/jbc.P113.525857

The authors concluded that their work “may help develop a drug for treating Friedreich ataxia associated with frataxin deficiency.”

See referenced article: Frataxin Directly Stimulates Mitochondrial Cysteine Desulfurase by Exposing Substrate-binding Sites, and a Mutant Fe-S Cluster Scaffold Protein with Frataxin-bypassing Ability Acts Similarly. J. Biol. Chem. 2013, 288, 36773–36786.