The role of PGC-1{alpha} on mitochondrial function and apoptotic susceptibility in muscle

Peter J. Adhihetty,² Giulia Uguccioni,^1,3 Lotte Leick,⁴ Juan Hidalgo,⁵ Henriette Pilegaard,⁴ and David A. Hood^1,2,3

¹School of Kinesiology and Health Science, ²Department of Biology, and ³The Muscle Health Research Centre, York University, Toronto, Ontario, Canada; ⁴Copenhagen Muscle Research Centre and Centre of Inflammation and Metabolism, Department of Biology, University of Copenhagen, Denmark, and ⁵Institute of Neurosciences and Department of Cellular Biology, Physiology and Immunology, Autonomous University of Barcelona, Barcelona, Spain

Submitted 12 February 2009 ; accepted in final form 5 May 2009

Keywords: endurance training; exercise; mitochondrial biogenesis; reactive oxygen species, cytochrome-c oxidase activity, brain, liver, pancreas.