MITOCHONDRIA: Mitochondrial OXPHOS (dys) function ex-vivo - the use of primary fibroblasts

MITOCHONDRIA: Mitochondrial OXPHOS (dys) function ex-vivo - the use of primary fibroblasts. Ann Saada, The International Journal of Biochemistry & Cell Biology, Available online 7 January 2014. http://dx.doi.org/10.1016/j.biocel.2013.12.010

Is summarized in this review the usefulness of fibroblasts in culture to verify and study the pathomechanism of new mitochondrial diseases and to evaluate the efficacy of individual treatment options.
The rationale for screening vitamins is that they frequently function as substrates and co-enzymes or as antioxidants and electron donors.