DRG-targeted helper-dependent adenoviruses mediate selective gene delivery for therapeutic rescue of sensory neuronopathies in mice

J. Clin. Invest. doi:10.1172/JCI39038

Copyright © 2009, The American Society for Clinical Investigation



DRG-targeted helper-dependent adenoviruses mediate selective gene delivery for therapeutic rescue of sensory neuronopathies in mice


Tomoya Terashima1, Kazuhiro Oka1,2, Angelika B. Kritz3, Hideto Kojima2, Andrew H. Baker3 and Lawrence Chan1,2
1Department of Medicine and 2Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas, USA. 3British Heart Foundation Glasgow Cardiovascular Research Centre, University of Glasgow, Glasgow, United Kingdom.
Address correspondence to: Lawrence Chan, Department of Medicine, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030, USA. Phone: (713) 798-4478; Fax: (713) 798-8764; E-mail: lchan@bcm.tmc.edu.



Published June 15, 2009



Full text: http://www.jci.org/articles/view/39038



Keywords: sensory neuronopathies, painful , DRG, therapeutic genes , dorsal root ganglion , adenoviruses, mice.