Idebenone: Novel Strategies to Improve Its Systemic and Local Efficacy

Lucia Montenegro, Rita Turnaturi, Carmela Parenti and Lorella Pasquinucci; Nanomaterials 2018, 8(2), 87; doi:10.3390/nano8020087

Due to IDE poor bioavailability after oral and topical administration, many researchers attempted different strategies to increase IDE efficacy in the treatment of neurodegenerative diseases and skin disorders. IDE chemical modifications mainly focused on increasing IDE activity at cellular or mitochondrial level while nanotechnology approaches aimed at designing novel formulations to improve IDE systemic and local efficacy. The encouraging results obtained loading IDE in different delivery systems such as liposomes, cyclodextrins and lipid-based nanoparticles could open new perspectives in the therapeutic outcomes of this strong antioxidant agent

 Idebenone: Novel Strategies to Improve Its Systemic and Local Efficacy