Iron Efflux from Oligodendrocytes Is Differentially Regulated in Gray and White Matter

The Journal of Neuroscience, 14 September 2011, 31(37): 13301-13311; doi: 10.1523/​JNEUROSCI.2838-11.2011

Katrin Schulz 1, Chris D. Vulpe 2, Leah Z. Harris 3, and Samuel David 1
1Center for Research in Neuroscience, The Research Institute of the McGill University Health Center, Montreal, Quebec H3G 1A4, Canada,
2Department of Nutritional Sciences and Toxicology, University of California, Berkeley, California 94720, and
3Department of Pediatrics, Vanderbilt University, Nashville, Tennessee 37232

Keywords: Accumulation of iron, neurodegenerative diseases, generate toxic free radicals, Iron homeostasis, ferroportin, ferroxidase, astrocytes, oligodendrocytes, hephaestin.

"Dysregulation of such efflux mechanisms leads to iron accumulation in the CNS."