Histone deacetylase inhibition activates transcription factor Nrf2 and protects against cerebral ischemic damage.

Free Radic Biol Med. Volume 52, Issue 5, 1 March 2012, Pages 928–936, http://dx.doi.org/10.1016/j.freeradbiomed.2011.12.006

Wang B, Zhu X, Kim Y, Li J, Huang S, Saleem S, Li RC, Xu Y, Dore S, Cao W.

Nanjing University Medical School, Jiangsu Key Lab of Molecular Medicine,
Nanjing, People's Republic of China; Department of Anesthesiology and Critical
Care Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205,
USA.

Keywords: histone deacetylase (HDAC), neuroprotection, multiple mechanisms, modulation of transcription, Nrf2, stroke, antioxidant-responsive genes, activation of Nrf2.