Expression of axonal protein degradation machinery in sympathetic neurons is regulated by nerve growth factor

J. Neurosci. Res.. (2012) doi: 10.1002/jnr.23041

Frampton, J. P., Guo, C. and Pierchala, B. A.

Keywords: proteasome, lysosome, NGF, transport, autophagy.

In Friedreich's ataxia research currently there is a work line about the frataxin's degradation by the proteasome , the idea is seeking to delay the degradation of frataxin, and therefore lengthen the shelf life.

References:

Preventing the ubiquitin/proteasome-dependent degradation of frataxin, the protein defective in Friedreich’s Ataxia

New project: Identification of the E3 ligase that ubiquitinates frataxin