Apn1 AP-endonuclease is essential for the repair of oxidatively damaged DNA bases in yeast frataxin-deficient cells

Apn1 AP-endonuclease is essential for the repair of oxidatively damaged DNA bases in yeast frataxin-deficient cells. Sophie Lefevre, Caroline Brossas, Françoise Auchère, Nicole Boggetto, Jean-Michel Camadro, and Renata Santos. Hum. Mol. Genet. first published online June 16, 2012 doi:10.1093/hmg/dds230

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KEYWORDS: Frataxin-deficiency, mitochondrial dysfunction, oxidative stress, Friedreich ataxia, respiratory deficit, disturbed iron homeostasis, sensitivity to oxidants, Apn1 enzyme, DNA damage.