Ocular-Motor Profile and Effects of Memantine in a Familial Form of Adult Cerebellar Ataxia with Slow Saccades and Square Wave Saccadic Intrusions

Ocular-Motor Profile and Effects of Memantine in a Familial Form of Adult Cerebellar Ataxia with Slow Saccades and Square Wave Saccadic Intrusions. Rosini F, Federighi P, Pretegiani E, Piu P, Leigh RJ, Alessandro Serra, Antonio Federico, Alessandra Rufa (2013). PLoS ONE 8(7): e69522. doi:10.1371/journal.pone.0069522

OPEN ACCESS, FULL TEXT PDF

Thus, our report suggests that memantine may have some general suppressive effect on saccadic intrusions, including both SWI and MSO, thereby restoring the capacity of reading and visual attention in these and in other recessive forms of ataxia, including Friedreich’s, in which saccadic intrusions are prominent.