Applying the Retro-Enantio Approach to Obtain a Peptide Capable of Overcoming the Blood–Brain Barrier

Applying the Retro-Enantio Approach to Obtain a Peptide Capable of Overcoming the Blood–Brain Barrier. Dr. Roger Prades, Benjamí Oller-Salvia, Dr. Susanne M. Schwarzmaier, Dr. Javier Selva, Dr. María Moros, Matilde Balbi, Dr. Valeria Grazú, Dr. Jesus M. de La Fuente, Prof. Gustavo Egea, Prof. Nikolaus Plesnila, Dr. Meritxell Teixidó and Prof. Ernest Giralt; Angewandte Chemie Intl Edition (February 2015) DOI: 10.1002/anie.201411408

"In conclusion, we report a protease-resistant peptide with the capacity to transport cargos of distinct sizes and types across the BBB, one of the most restrictive barriers in the human body.
This potential BBB shuttle brings with it the possibility to fulfil an unmet clinical need, namely the treatment of CNS disorders."