Translation of Human-Induced Pluripotent Stem Cells: From Clinical Trial in a Dish to Precision Medicine

Nazish Sayed, Chun Liu, Joseph C. Wu, Journal of the American College of Cardiology, Volume 67, Issue 18, 10 May 2016, Pages 2161-2176, ISSN 0735-1097, doi:10.1016/j.jacc.2016.01.083.

Human-induced pluripotent stem cells (iPSCs) provide a new source of therapeutic cells free from the ethical issues or immune barriers of human embryonic stem cells. iPSC technology has expanded with 3 major applications: disease modeling, regenerative therapy, and drug discovery. Here we discuss, in a comprehensive manner, the recent advances in iPSC technology in relation to basic, clinical, and population health.

 Translation of Human-Induced Pluripotent Stem Cells: From Clinical Trial in a Dish to Precision Medicine