Metal Homeostasis Regulators Suppress FRDA Phenotypes in a Drosophila Model of the Disease

Soriano S, Calap-Quintana P, Llorens JV, Al-Ramahi I, Gutiérrez L, Martínez-Sebastián MJ, Juan Botas, María Dolores Moltó. PLoS ONE 11(7): e0159209. doi:10.1371/journal.pone.0159209

Open Access (Creative Commons Attribution License)

We report several novel genetic modifiers of eye morphology and motor dysfunction in the FRDA fly model. These data provide further support for the notion that disruptions in metal homeostasis may be a primary contributor to FRDA disease pathogenesis.

 Metal Homeostasis Regulators Suppress FRDA Phenotypes in a Drosophila Model of the Disease