miRNAs as biomarkers of neurodegenerative disorders

Vijitha Viswambharan, Ismail Thanseem, Mahesh M Vasu, Suresh A Poovathinal, and Ayyappan Anitha; Biomarkers in Medicine, February 2017 ,Vol. 11, No. 2 , Pages 151-167 doi: 10.2217/bmm-2016-0242

The potential role of epigenetic changes associated with FRDA including miRNA-based regulatory mechanisms is being studied now. Genetic variations that create miRNA target sites in the 3′-UTR of FXN have been found to affect frataxin expression in FRDA. For example, miRNA-145 has been found to directly bind to the 3′-UTR region of FXN, negatively regulating its expression.


 miRNAs as biomarkers of neurodegenerative disorders