Mechanisms of iron- and copper-frataxin interactions

Thi Hong Lien Han, Jean-Michel Camadro, Renata Santos, Emmanuel Lesuisse, Jean Michel El Hage Chahine and Nguyêt Thanh Ha-Duong; Metallomics, 2017, Accepted Manuscript. DOI:10.1039/C7MT00031F

Frataxin deficient Δyfh1 yeast cells exhibited a marked growth defect in the presence of exogenous Cu or Mn. Mitochondria from Δyfh1 strains accumulated also higher amounts of copper, suggesting a functional role of frataxin in vivo in copper homeostasis.


Mechanisms of iron- and copper-frataxin interactions