Epigenetic Regulation in Neurodegenerative Diseases

Amit Berson, Raffaella Nativio, Shelley L. Berger, Nancy M. Bonini, Trends in Neurosciences, Available online 7 June 2018, ISSN 0166-2236, doi:10.1016/j.tins.2018.05.005.

Mechanisms of epigenetic regulation, including DNA methylation, chromatin remodeling, and histone post-translational modifications, are involved in multiple aspects of neuronal function and development. Recent discoveries have shed light on critical functions of chromatin in the aging brain, with an emerging realization that the maintenance of a healthy brain relies heavily on epigenetic mechanisms. Here, we present recent advances, with a focus on histone modifications and the implications for several neurodegenerative diseases including Alzheimer’s disease (AD), Huntington’s disease (HD), and amyotrophic lateral sclerosis (ALS). We highlight common and unique epigenetic mechanisms among these situations and point to emerging therapeutic approaches.

 Epigenetic Regulation in Neurodegenerative Diseases