In Vitro interaction between yeast frataxin and superoxide dismutases: Influence of mitochondrial metals

Thi Hong Lien Han, Jean-Michel Camadro, Florent Barbault, Renata Santos, Jean-Michel El Hage Chahine, Nguyet-Thanh Ha-Duong; Biochimica et Biophysica Acta (BBA) - General Subjects, Volume 1863, Issue 5, 2019, Pages 883-892, ISSN 0304-4165, doi:10.1016/j.bbagen.2019.02.011.

Friedreich's ataxia results from a decreased expression of the nuclear gene encoding the mitochondrial protein, frataxin. Frataxin participates in the biosynthesis of iron-sulfur clusters and heme cofactors, as well as in iron storage and protection against oxidative stress. How frataxin interacts with the antioxidant defence components is poorly understood.




In Vitro interaction between yeast frataxin and superoxide dismutases: Influence of mitochondrial metals