Frataxin Deficit Leads to Reduced Dynamics of Growth Cones in Dorsal Root Ganglia Neurons of Friedreich’s Ataxia YG8sR Model: A Multilinear Algebra Approach

Muñoz-Lasso DC, Mollá B, Sáenz-Gamboa JJ, Insuasty E, de la Iglesia-Vaya M, Pook MA, Pallardó FV, Palau F and Gonzalez-Cabo P (2022). Front. Mol. Neurosci. 15:912780. doi: 10.3389/fnmol.2022.912780

In summary, we have evidenced an adverse effect of the deficit of frataxin in the formation and, most importantly, the growth cones’ function in adult DRG neurons by applying both classical and novel computer-assisted analysis. As a result, we propose that frataxin deficient DRG neurons might lose the intrinsic capacity to grow and regenerate axons properly due to the dysfunctional GCs they build.

Frataxin Deficit Leads to Reduced Dynamics of Growth Cones in Dorsal Root Ganglia Neurons of Friedreich’s Ataxia YG8sR Model: A Multilinear Algebra Approach