We observed increased phosphorylation of AKT and dysregulation of multiple downstream effectors of mTORC1, including S6K1, S6, ULK1 and 4EBP1, in a cardiac/skeletal muscle specific FRDA conditional knockout (cKO) mouse model and in human cell lines depleted of ISC biogenesis factors.
Wednesday, August 31, 2022
Hyperactivation of mTOR and AKT in a cardiac hypertrophy animal model of Friedreich ataxia
Wing-Hang Tong, Hayden Ollivierre, Audrey Noguchi, Manik C. Ghosh, Danielle A. Springer, Tracey A. Rouault; Heliyon, Volume 8, Issue 8, 2022.
