Frataxin deficiency in proprioceptive neurons is causal to inflammatory and glial responses in dorsal root ganglia

Frataxin deficiency in proprioceptive neurons is causal to inflammatory and glial responses in dorsal root ganglia, Pauline Meriau, Laure Weill, Hélène Puccio, Cendra Agulhon, bioRxiv 2024.04.16.589410; doi:10.1101/2024.04.16.589410 

Our study revealed that proprioceptor FXN deficiency causes major changes in inflammatory macrophage and SGC gene transcription as well as macrophage and SGC number, highlighting molecular and cellular pathways that were sequentially altered, thus representing temporal signatures of FA ganglionopathy progression.

Frataxin deficiency in proprioceptive neurons is causal to inflammatory and glial responses in dorsal root ganglia