We further overexpressed Tspo specifically in glial cells and observed improved survival. Finally, we investigated the effects of Tspo overexpression in healthy flies. Increased longevity was conferred by glial-specific overexpression, with opposite effects in neurons. Overall, this study highlights protective effects of glial TSPO in Drosophila both in a neurodegenerative and a healthy context.
Sunday, May 26, 2024
Glial overexpression of Tspo extends lifespan and protects against frataxin deficiency in Drosophila
Estelle Jullian, Maria Russi, Ema Turki, Margaux Bouvelot, Laura Tixier, Sandrine Middendorp, Elodie Martin, Véronique Monnier,
Glial overexpression of Tspo extends lifespan and protects against frataxin deficiency in Drosophila,
Biochimie, 2024, ISSN 0300-9084, doi:10.1016/j.biochi.2024.05.003.
