Altered calcium responses and antioxidant properties in Friedreich’s ataxia-like cerebellar astrocytes

Altered calcium responses and antioxidant properties in Friedreich’s ataxia-like cerebellar astrocytes Chiara Marullo, Laura Croci, Iris Giupponi, Claudia Rivoletti, Sofia Zuffetti, Barbara Bettegazzi, Filippo Casoni, Ottavio Cremona, Gian Giacomo Consalez, Franca Codazzi bioRxiv 2024.07.19.604129; doi: 10.1101/2024.07.19.604129 

Our findings shed light on cellular changes caused by FXN downregulation in cerebellar astrocytes, which can interfere with their physiological and complex interaction with neurons. The potentially impaired ability to provide neuronal cells with glutathione or to release neuromodulators and bioactive molecules in a calcium-dependent manner could impact neuronal function and contribute to neurodegeneration.

Altered calcium responses and antioxidant properties in Friedreich’s ataxia-like cerebellar astrocytes